1. Proteins are made at the ribosomes
2. The ribosomes on the rough endoplasmic reticulum (ER) make proteins that are excreted or attached to the cell membrane. The free ribosomes in the cytoplasm make proteins that stay in the cytoplasm
3. New proteins produced at the rough ER are folded and processed (e.g. sugar chains are added) in the rough ER
4. Then they're transported from the ER to the Golgi apparatus in vesicles
5. At the Golgi apparatus, the proteins may undergo further processing (e.g. sugar chains are trimmed or more are added)
6. The proteins enter more vesicles to be transported around the cell. e.g. extracellular enzymes (like digestive enzymes) move to the cell surface and are secreted