For many single-celled organisms, diffusion, osmosis, and active transport are all that is needed to exchange materials with their environment because they have a relatively large surface area compared to the volume of the cell
Surface area to volume ratio is also important when you consider how energy is transferred by living organisms, and how water evaporates from the surfaces of plants and animals
As the distances between the centre of the organism and the surface get bigger, simple diffusion is no longer enough to exchange materials between the cells and the environment
Have a large surface area over which exchange can take place
Have a thin membrane or being thin to provide a short diffusion path
In animals, have an efficient blood supply that moves the diffusing substances away from the exchange surfaces and maintains a steep concentration (diffusion) gradient
In animals, are ventilated to make gas exchange more efficient by maintaining steep concentration gradients