all gases move down a pressure gradient from an area of high to low partial pressure, diffusing from the alveolar air to the capillary blood and then to the muscle cells. the greater the diffusion gradient, the faster the oxygen will move from one area to another. at rest, the pO2 in the deoxygenated capillary blood arriving back at the alveoli is around 40mmHg. the greater the altitude, the greater the negative impact on the diffusion gradient