For Lady Macbeth, on the other hand, her guilt and paranoia only manifest fully in her final scenes. At the start, she orchestrates the murder and silences all of Macbeth's fears and regrets. There are subtle indications that she isn't as confident and cold as she wants to seem, but her speech is controlled and cutting. Eventually, she is completely unaware of Macbeth's actions. This division that forms both physically and mentally between the couple portrays guilt as isolating.