Drugs

• Adrenaline(anaphylaxis)


  Vasoconstrictor and bronchodilator that counteracts the vasodilation and bronchoconstriction induced by histamine and other inflammatory mediators
• Administering adrenaline(anaphylaxis)


  1. Every 5mins

  2. Helps stabilize mast cells

  3. Mitigate vasodilation

  4. Improve BP

  5. Improve tissue perfusion

  6. Relieve airway constriction
• Oxygen


  High-flow oxygen supplementation helps to improve oxygenation (92-96%)
• Salbutamol


  Sympathomimetic affecting B2 adrenoreceptors
• Ipratropium Bromide


  Antimuscarinic agent which promotes bronchodilation by inhibiting cholinergic bronchomotor tone
• Ondansetron


  Anti-emetic, Serotonin 5HT3 receptor antagonist, Blocks action of serotonin (which may cause nausea/vomiting)
• Fentanyl


  Synthetic narcotic analgesic, Acts on CNS by binding with opioid receptors, Binding of opioid receptors results in a decrease in intracellular cAMP which results in inhibition of nociceptive neurotransmitters
• Morphine


  Narcotic analgesic, Acts on CNS by binding with opioid receptors, Altering processes affecting pain perception and emotional response to pain, Causes respiratory depression, vasodilation, decreased gag reflex and slows AV node conduction, Binding of opioid receptors results in a decrease in intracellular cAMP which results in inhibition of nociceptive neurotransmitters
• Magnesium Sulphate


  Electrolyte, Causes vasodilation and bronchodilation through inhibition of smooth muscle contraction, Magnesium ions process anticonvulsant and anti-dysrhythmic properties
• Glyceryl Trinitrate


  Vasodilator, Decreases preload by increasing venous capacity, pooling venous blood in the peripheral veins, reducing ventricular filling pressure and decreasing arterial blood pressure (afterload), This results in a decrease in myocardial oxygen demand, although a reflex tachycardia may offset this