how do Psychological or behavioral factors adversely affect the medical condition?
– factors have influenced course of medical condition as shown by close temporal association between the psychological factors and the development or exacerbation of, or delayed recovery from, the medical condition
– interfere with the treatment of the medical condition (e.g., poor adherence)
– constitute additional well-established health risks for individual
– influence underlying pathophysiology, precipitatin, exacerbating symptoms or necessitating medical attention