Late 18th and early 19th century prevention
1. Rise of the scientific method: microscopes, stethoscopes, scientific papers being published
2. John Snow observed that in an area of very high cholera cases, the men working in the brewer who drank beer instead of water didn't get sick, so he forced them to stop using the contaminated water pump
3. Edward Jenner observed that local dairy maids seemed to be immune from smallpox and believed they had immunity because they'd had cowpox, so he inoculated a small boy with cowpox and then smallpox - it had no effect