Enzymes

• A higher activation energy corresponds to a slower reaction.
• Catalysts speed up reaction rates by lowering activation energy.
• Binding energy is a major source of free energy used by enzymes to lower the activation energies of reactions.
• Optimal interactions between substrate and enzyme occur only in the transition state.
• At low concentrations of substrate, Vo increases almost linearly with an increase in [S].
• At high substrate concentrations, Vo decreases in response to increase [S].
• How do catalysts speed up reactions?

  By lowering activation energy