The biological explanation of OCD can be criticised for biological reductionism. This is because it reduces complex human behaviour of OCD down to simple basic units of genes (SERT). For example, a mutation in the SERT gene. This neglects a holistic approach, which would take into account how a person's cultural context could influence OCD; research has shown that there is a higher prevalence of OCD in certain religious groups where regular cleansing before prayer is obligatory. Therefore, the biological explanation may lack validity as it doesn't allow us to understand behaviour in context.