BIO 30 EXAM 2
Cards (25)
- Linkage in sweet peas
- linkage in drosophilia
- used linkage for chromosome mapping
- association of sex characteristics with particular chromosomes
- Barr body at interphase of nucleus in female humans, cats, mice
- confirmed Barr body through lyonization / x-inactivation
- isolated a molecule different from protein and called it DNA
- discovered nucleus as the msot obvious cellular component
- used staining technique to discover DNA as the most important nuclear element
- identified that the transforming principle is DNA
- used blender experiment to prove DNA as the genetic material of bacterial viruses
- used transduction experiment in salmonella typhimurium to prove DNA as genetic material
- from kings college london, studied DNA structure using x-ray diffraction
- from cambridge university, studied DNA structure and won noble prize
- proved purine-pyrimidine ratio is 1:1
- discovered hydrogen in the bases can change position
- nucleotides are flat, stack on top of another
- studied alkaptonuria and relationship between gene and specific enzyme
- one gene-one enzyme hypothesis
- constructed synthetic mRNA with different nucleotide combinations
- proposed the need for genetic coding system
- made synthetic RNAs using polynucleotide phosphorylate
- produced artificial mRNA introduced into cell free system
- transformation experiment using streptococcus pneumonia confirmed transforming principle
- found DNA replication to be sem-conservative