20- OSTEOMALACIA

• Clinical manifestations


  • May be asymptomatic
  • Proximal muscle weakness & pain
• If severe vitamin D deficiency


  • Hypocalcemia
  • Tetany
  • Seizures
• Investigations


  1. Serum 25-hydroxyvitamin D3 is low

  2. Alkaline phosphatase is high

  3. PTH is high
• Management


  1. Initial loading stage to replenish stores

  2. Subsequent maintenance phase to avoid repeat deficiency

  3. Supplementary calcium is also given
• Definition: clinical manifestations of profound Vitamin D deficiency following epiphyseal closure in adults.