Stages of intramembranous ossification
1. Ossification center appears in fibrous connective tissue membrane
2. Selected centrally located mesenchymal cells cluster and differentiate into osteoblasts, forming an ossification center
3. Bone matrix (osteoid) is secreted within the fibrous membrane
4. Osteoblasts begin to secrete osteoid, which is mineralized within a few days
5. Trapped osteoblasts become osteocytes
6. Woven bone and periosteum form
7. Accumulating osteoid laid down between embryonic blood vessels, which form a random network = network of trabeculae
8. Vascularized mesenchyme condenses on the external face of woven bone and becomes periosteum
9. Bone collar of compact bone forms and red bone marrow appears
10. Trabeculae just deep to the periosteum thicken, forming a woven bone collar that is later replaced with mature lamellar bone
11. Spongy bone (dipole) consisting of distinct trabeculae, persists internally and its vascular tissue becomes red marrow