treatments

• Sibutramine reduces appetite by potentiating noradrenaline and serotonin signalling
• rimonabant reduces appetite by antagonising central type-1 cannaboid receptors
• Sibutramine - hypertension. Rimonabant - psych/reproduc. issues. both modest weight reduction
• most obese humans have high circulating leptin and are resistant to its metabolic affects
• mechanoreceptors and chemoreceptors in the GIT signal through the vagal nerve to the brain stem
• Ghrelin produced in stomach. binds to ghs-r to cross blood-brain barrier. stimulates food intake and growth hormone release.
• ghrelin promotes not using fat for energy
• Peptide YY is made in L cells throughout the cut, increasing in concentration as you go further along. Acutely inhibits feedig