Stage 1 : Neurogenesis

• STAGE 1: NEUROGENESIS

  • neurogenesis -is made up of the words “neuro” meaning “relating to nerves” and “genesis” meaning the formation of something.
  • differentiated will undergo mitosis to produce either stem cells, or neuroblasts,
  • cells continue dividing until they eventually form what is called the “ventricular zone,”
  • This ultimately leads to the formation of three separate zones: the
  • ventricular zone,
  • intermediate zone,
  • marginal zone.
• CELL DEATH - large numbers of cells die in the process known as "apoptosis" it means falling leaves
• neurotrophin - Substance released by target cells that contributes to the survival of presynaptic neurons.
• nerve growth factor (NGF) - The first identified neurotrophin.
• caspase - An enzyme within a cell that cuts up DNA and produces cell death.

  • When neurotrophic factors bind to receptors on a neuron, caspase activity is inhibited, and the cell survives.
• Cell death gene - A gene responsible for triggering the activity of caspases, leading to apoptosis.
• Cell death - serves important functions in the developing nervous system.

  • Too many surviving cells might result in problems.