"He is a good and a great man, but he forgets, pitilessly, the feelings and claims of little people, in pursuing his own large views." (about St John)
"good and great man" --> dedicated to his (missionary) work
Despite his admirable qualities, he exhibits a lack of empathy and compassion
"In pursuing his own large views" --> His ambitions and goals take precedence. Sees Jane primarily as a tool for his own ambitions, pressuring her to marry him; willing to sacrifice her happiness and autonomy to fulfill his own mission --> male domination; women's needs are subordinated to men's