According to the book of Bellew J. W., underlying the process of iontophoresis is the electrical repulsion of ions. Using ES to moved charged ions into the target tissues has long been the cornerstone explanation for iontophoresis. And, according to Swati Rawat, it is for movement of ions to improved systemic bioavailability. For example, when you apply the law of repulsion in iontophoresis due to muscle spasm, the drug will control and will deliver accurately where affected tissue locates so that to aim and treat what the target area.