One limitation of drug treatment for OCD is that drugs can have potentially serious side effects. While SSRIs can be effective for many patients, a significant minority may not experience any benefit. Additionally, some patients may experience undesirable side effects. For example, Clomipramine, a tricyclic antidepressant, is associated with more common and severe side effects, such as erection problems, tremors, and weight gain in more than 1 in 10 patients.