repetition shows she needs to be in bed as she is a victim of treason and cannot deal with the guilt. If someone commits regicide, they go crazy (divineright of kings).
"All the perfumes of Arabia would not sweeten this hand." - ladymacbeth
(metaphor) not even the bestsmells can take her guilt away. (hyperbole) the smell of guilt is so strong that nothing can replace it.
"Out damned spot! Out I say!" - lady macbeth
she is hallucinating which shows her guilt as she has been made unstable by the crimes that she has comitted. Repetition of "out" emphasises her madness resulting from this guilt.
"sleep no more" - macbeth
guilt after killing Duncan causes Macbeth to lose sleep as his mind is riddled with remorse. Shakespear warns the audience about comitting regicide as it goes against the divineright of kings and makes you unstable.