cell mediated immunity

• CMI is also called cellular immunity
• 2 types of T cells are: killer T cells and suppressor T cells
• Helper T cells promote phagocytosis by macrophage
• Certain T-lymphocytes stimulated and undergo rapid cell division
• some sensitised T cell form memory cells
• killer T cell?

  Attach to invading cells and secretes toxin that destroys AG
• what is CMI?

  Resistance to intercellular phase of bacterial and viral infection

  • Production and release of 3 different kinds of cells
• process of CMI?

  intracellular phase

  1. AG presented to specific T cell by macrophage or B cell
  2. T cell sensitised and hence divides into a clone
• what does T cell, once sensitised, divide into?

  Some: memory cells

  Rest are further developed T-cells with specialised functions:

  • Killer T cell: Attach to invading cells and secretes toxin that destroy AG
  • Helper T cell: Secrete substance that further sensitise T cells; attract macrophages to infection site and increase their phagocytic activity
  • Suppressor T cell: secrete substances that inhibit actions of T cells once infection dealt with
• helper t cells?

  Secrete substance that further sensitise T cells; attract macrophages to infection site and increase their phagocytic activity
• Helper t Cell?

  Secrete substance that further sensitise T cells

  • attract macrophages to infection site
  • Increase their phagocytic activity
• what does T cell, once sensitised, divide into?

  Some: memory cells

  Rest are further developed T-cells with specialised functions:

  • Killer T cell: Attach to invading cells and secretes toxin that destroy AG
  • Helper T cell: Secrete substance that further sensitise T cells; attract macrophages to infection site and increase their phagocytic activity
  • Suppressor T cell: secrete substances that inhibit actions of T cells once infection dealt with
• FULL PROCESS?

  t cells in lymph have AG receptors on surface

  1. macrophages display non-self AG from bacteria/virus
  2. AG presenting macrophages migrate to lymph node
  3. specific T cells recognise specific non-self AG
  4. T cells sensitised: enlarge and form clones:
• full process?

  t cells in lymph have AG receptors on surface

  1. macrophages display non-self AG from bacteria/virus
  2. AG presenting macrophages migrate to lymph node
  3. specific T cells recognise specific non-self AG
  4. T cells sensitised: enlarge and form clones:

  some: memory cells

  • Killer T cell: Attach to invading and secretes toxin destroy AG
  • Helper T cell: Secrete substance that further sensitise T cells; attract macrophages to infection site and increase their phagocytic activity
  • Suppressor T cell: secrete substances that inhibit actions of T cells once infection dealt with
• full process?

  T cells in lymph have AG receptors on surface

  1. macrophages display non-self AG from bacteria/virus
  2. AG presenting macrophages migrate to lymph node
  3. specific T cells recognise specific non-self AG
  4. T cells sensitised: enlarge and form clones:

  some: memory cells

  • Killer T cell: Attach to invading and secretes toxin destroy AG
  • Helper T cell: Secrete substance that further sensitise T cells; attract macrophages to infection site and increase their phagocytic activity
  • Suppressor T cell: secrete substances that inhibit actions of T cells once infection dealt with