macbeth- 'Thy bones are marrowless, thy blood is cold, Thou hast no speculation in those eyes'
speaks this line when Banquo's ghost appears to him at the banquet. - His vision of the ghost reveals the guilt of ordering the murderer of Banquo and his young son.- he is losing his sanity
Macbeth- ' will all great Neptune's ocean wash this blood clean from my hand?'
after murdering Duncan.- Talking about literal blood, but also his sense of guilt