L4-6 quiz

• how do antibodies enable destruction of a pathogen:

  • recruit complement proteins to enable production of a membrane attack complex, resulting in lysis of the pathogen
  • enable precipitation of soluble antigens facilitating phagocytosis
  • opsonise pathogens facilitating phagocytosis
• infected cells display processed antigen molecules on their surface via MHC I
• CD8 T cell receptors bind to antigen displayed on the surface of infected cells
• CD8 T cells release perforins and granzymes which destroy the infected cell
• CD8 on the surface of the cytotoxic T lymphocytes bind to MHC I on the surface of the infected cell
• CTL stands for 


  cytotoxic T lymphocyte
• the primary immune response is slower than the secondary immune response
• the secondary immune response can originate from memory B cells
• the primary immune response originates from naive B cells
• the secondary response to an antigen lasts longer than the primary immune response
• the primary immune response takes over a week to become effective
• human influenza virus strains preferentially bind to sialic acids with alpha 2-6 linkage
• avian influenza virus strains prefer to bind to sialic acid with alpha 2-3 linkage
• helper T cells are vitally important in the acquired immune response because they enable full activation of both the humoral and cell-mediated immune responses
• CD8 T cells are activated by antigens presented by an infected or cancerous cell
• CD8 T cells bind to an infected cell via:

  • binding of the T cell receptors with specific antigen presented on the surface of the infected cell
  • by the interaction of the MHCI on the surface of the infected cell with the CD8 on the cytotoxic T cell
• M2 blockers inhibit uncoating of the virus and prevent it from entering the cell