L7-9 quiz

• Wuchereria bancrofti is transmitted by a mosquito
• nematode parasite intensity of infection is important, not prevalence
• Nematodes don't undergo asexual reproduction in their life cycle
• Ascaris lumbricoides is transmitted through the faecal oral route
• bubo in bubonic plague means an enlarged lymph node
• 5 species of Plasmodium commonly infect humans
• which species of Plasmodium is the most pathogenic to humans?

  Plasmodium falciparum
• the pathogen that causes the plague is a bacterium
• merozoites are the life cycle stage of the Plasmodium responsible for invading re blood cells
• sporozoites are the life cycle stage of Plasmodium responsible for invading the liver cells
• malaria is transmitted by mosquitoes
• mosquito: a slender long-legged fly with aquatic larvae. The bite of the bloodsucking female can transmit a number of serious diseases including malaria and elephantiasis
• mosquitoes are the definitive host for plasmodium
• sequestration by the malarial parasite is responsible for cerebral malaria (a clinical symptom of malaria)
• humans can become infected with the plague by:

  • bite of an infected flea
  • unprotected contact with infectious bodily fluids or contaminated materials
  • inhalation of respiratory droplets exhaled from a patient with pneumonic plague
• in endemic populations


  number of worms in an individual host is over dispersed
• chloroquine (CQ) is a lysosomotropic drug, is a weak base, uncharged at neutral pH, but at acidic pH chloroquine carrier a positive charge
• uncharged chloroquine rapidly diffuses through both the parasite plasma and food vacuole membranes, when the food vacuole becomes acidified, chloroquine becomes charged and is trapped within the food vacuole
• most common form of the plague is

  bubonic