1. Electrical impulse arrives at the end of the axon on the presynaptic neurone
2. Chemical messengers (neurotransmitters) are released from vesicles at the presynaptic membrane
3. Neurotransmitters diffuse across the synaptic cleft
4. Neurotransmitters temporarily bind with receptor molecules on the postsynaptic membrane
5. Postsynaptic neurone generates an electrical impulse that travels down the axon
6. Neurotransmitters are destroyed or recycled to prevent continued stimulation of the second neurone