Have you ever wondered why it is so important for genetic material to be replicated exactly? Each living creature has a different genetic code that carries instructions for its own production. How do the genetic instructions for wombats differ from those for koalas, dogs, penguins or even mushrooms? Parents give rise to offspring of the same species, with a similar genetic makeup to their own, so they can survive in the same environment. It is essential that organisms pass on their own unique genetic instructions or information from one generation to the next, to ensure the continuity of the species.
How can something as tiny as a cell carry all the instructions needed to make a large, complex, living organism? When scientists began searching for the 'code of life' in cells, they realised that the genetic code would need to be in molecular form to be small enough to fit all the instructions into a cell. As chromosomes are composed of DNA (deoxyribonucleic acid) and protein, scientists deduced that the genetic code must be carried by one of these two macromolecules – either in proteins or in DNA.
It was expected that the genetic code would be complex, because it needs to store large amounts of information accurately over long periods of time. The genetic code would also need to be copied exactly and any errors that arose during copying would need to be easily fixed. Most scientists favoured protein as the carrier of the genetic instructions, because proteins are complex and varied, being made up of at least twenty different amino acids.
It is essential that organisms pass on their own unique genetic instructions or information from one generation to the next, to ensure the continuity of the species
Most scientists favoured protein as the carrier of the genetic instructions, because proteins are complex and varied, being made up of at least twenty different amino acids
Genetic information can be carried by a molecule that uses an 'alphabet' made up of only four 'letters': the bases adenine (A), cytosine (C), guanine (G) and thymine (T)
In the decade following 1953, the combined work of many scientists led to an understanding of how the information in DNA can lead to specific proteins being produced