Estrogen

• Estrogen is a steroid hormone that can act affect transcription
• Estrogen affects transcription by binding to an ERa estrogen receptor- TRANSCRIPTION FACTOR
• The protein changes shape and forms an estrogen-estrogen receptor complex which moves from the cytoplasm to the nucleus where it binds to a promotor region with the help of cofactors
• the estrogen-estrogen receptor complex like other transcription factors helps RNA polymerase to bind and activates transcription