research suggest that depression is a biological condition, through the finding of lower serotonin levels in patients with depression. In addition, drug therapies, including SSRIs, which increase the level of serotonin, are found to be effective in the treatment of depression, and Mcguffin et al found that the concordance rates for depression were higher in monozygotic twins (46%) than dizygotic twins (20%), concluding that depression is at least partially explained by the biological approach.