The genetic makeup of an individual based on the genetic material (DNA) inherited from one's genetic contributors
Phenotype
An individual's observable characteristics, such as hair color, skin color, height, and build
Genotype and phenotype are determined by the interaction of genetic material supplied by the sperm and egg
Allele
A specific version of a gene
Dominant allele
Having the dominant allele either from one parent (Bb) or both parents (BB) will always result in the phenotype associated with the dominant allele
Recessive allele
An individual will only display the phenotype if they are homozygous for that recessive allele (bb)
Homozygous
Having two copies of the same allele
Heterozygous
Having a combination of alleles for a given gene
Most traits are controlled by multiple genes, but some traits are controlled by one gene
Cleft chin is a dominant trait, while smooth chin is a recessive trait
If a person with a cleft chin mates with a person with a smooth chin
The offspring's chin type depends on which alleles each parent carries
Cleft chin
Dominant trait
Smooth chin
Recessive trait
Offspring phenotype when cleft chin parent mates with smooth chin parent
1. Depends on which alleles each parent carries
2. If cleft chin parent is homozygous, offspring will always have cleft chin
3. If cleft chin parent is heterozygous, offspring have 50% chance of cleft chin and 50% chance of smooth chin
Punnett square is a tool used to predict how genes will interact in the production of offspring
Sickle cell anemia is a genetic disorder caused by the pairing of two recessive genes
Phenylketonuria (PKU) is a condition in which individuals lack an enzyme that normally converts harmful amino acids into harmless byproducts
If two individuals mate who are both heterozygous for the allele associated with PKU
Their offspring have a 25% chance of expressing the PKU phenotype
Mutation
A sudden, permanent change in a gene
Diversity in genes and associated traits allows some individuals to perform slightly better than others when faced with environmental change
Race is not a useful variable in genetic research and its continued use represents a potential source of confusion and harm
Range of reaction
Our genes set the boundaries within which we can operate, and our environment interacts with the genes to determine where in that range we will fall
Genetic environmental correlation
Our genes influence our environment, and our environment influences the expression of our genes
Epigenetics
The study of how the same genotype can be expressed in different ways
Identical twins share the same genetic information but can have different phenotypes due to epigenetic factors
Adoptees with high genetic risk for schizophrenia
Were much more likely to develop schizophrenia if raised in a disturbed family environment
The study on schizophrenia in adoptees shows that both genetic vulnerability and environmental stress are necessary for the disorder to develop
Glial cells
Cells that provide scaffolding, insulation, and support for neurons
Neurons
Interconnected information processors that are essential for all tasks of the nervous system
Neurons
Consist of a semipermeable membrane, nucleus in the soma, branching dendrites, axon, and terminal buttons
Neuronal communication
1. Electrical signal moves down the axon
2. Neurotransmitters released into synaptic cleft
3. Neurotransmitters bind to receptors on adjacent neuron
Membrane potential
Difference in charge across the neuronal membrane that provides energy for the signal
Resting potential
State of readiness where ions are lined up ready to move across the membrane when the neuron becomes active
Sodium (Na+) is at higher concentrations outside the cell
Sodium tends to move into the cell
Potassium (K+) is more concentrated inside the cell
Potassium tends to move out of the cell
Inside of the cell is slightly negatively charged compared to outside
Provides an additional force causing sodium to move into the cell
The sodium-potassium pump actively transports three sodium ions out of the cell for every two potassium ions in, creating a net negative charge inside the cell
Loss of the myelin sheath insulation can be detrimental to normal neuronal function, as seen in disorders like PKU and multiple sclerosis
Specific neurotransmitters fit specific receptors in a lock-and-key relationship