The synaptic vesicles containing the neurotransmitter are only present on/released from the presynaptic membrane and the receptors for the neurotransmitters are only present on the postsynaptic membrane. It is the binding of the neurotransmitter to the receptor which enables the signal/information to be passed/transmitted on (to the next neuron). Diffusion of the neurotransmitters mean they can only go from high to low concentration, so can only travel from the presynaptic to the postsynaptic membrane. This means neurons can only transmit information in one direction at a synapse.