Limbic system and aggression
Firstly, the hippocampus is involved in the formation of long-term memories which allows animals/humans to compare a current threat with similar past experiences. For example, if an animal who has previously been attacked encounters that or a similar animal again, they may be more likely to respond in a fearful or aggressive manner. Impaired hippocampus function also prevents the nervous system from putting things into meaningful context and may lead to amygdala to respond to sensory stimuli with aggression.
Secondly, the most important structure linked to aggression by far is the amygdala whose role is to process emotion. If the amygdala in humans malfunctions due to a tumour, damage or atypical development, then this can lead to raised levels of testosterone, making aggression more likely.
Finally, the hypothalamus is responsible for the regulation of the autonomic nervous system, which in turn regulates responses to emotional circumstances. Therefore, damage to this area can result in an inappropriate aggressive response to a perceived threat.