Clotting cascade

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    Created by
    Pierre Gasly

    Cards (57)

    • What are the main proteins in plasma
      Fibrinogen.
      Albumin.
      Globulins.
    • How much of plasma is water
      90 %
    • How much protein is plasma
      7 - 9 %
    • Where are plasma proteins synthesised
      In the liver
    • Which plasma protein is not synthesised in the liver
      Gamma globulins.
    • How are plasma proteins seperated
      Using serum electrophoresis they are separated base on charge.
    • What charge do plasma proteins have
      negative
    • What are gamma globulins
      They are immunoglobulins
    • Label the serum electrophoresis and state which plasma protein is not present.
      Fibrinogen is not present in serum samples.
      A) Albumin
      B) Alpha 1
      C) Alpha 2
      D) Beta
      E) Gamma
    • Which plasma protein has the highest charge
      Albumin
    • Which plasma protein has the lowest charge
      Gamma globulins
    • Which plasma proteins has the highest Mr
      Fibrinogen
    • Which plasma protein has the lowest Mr
      Albumins
    • What proteins transport T4 and T3
      Albumin and thyroglobulin.
    • What is coronary thrombosis
      A blood clot in the coronary vessels
    • What is a non-haemorrhagic stroke
      It is due to the blockage of an artery in the brain causing ischaemia.
    • What is a haemorragic stroke
      It is caused by bleeding in the brain
    • What is a pulmonary embolis
      When a blood clot travels to a pulmonary blood vessel.
    • What is haemostasis 

      The process by which the body stops bleeding
    • What is haemorrhage

      Bleeding is caused by ineffective haemostasis.
    • What are the main parts of haemostasis
      1. Primary
      2. Secondary
    • What are the parts of primary haemostasis
      Vasoconstriction.
      Platelet activation caused by exposure to collagen which causes a platelet plug to form.
    • What are the parts of secondary haemostasis
      The coagulation cascade is stimulated by tissue and platelet factors to produce a blood clot.
      Antithrombotic control mechanisms control the cascade.
    • Briefly describe haemostasis
      Vasoconstriction.
      A platelet plug forms and is converted into a blood clot using fibrin.
      Plasmin causes fibrinolysis, and the clot is degraded.
    • Describe vascular constriction in blood coagulation
      Stimulated by serotonin, endothelins and tissue factors.
    • How long does platelet plug formation take
      Seconds
    • How long does the fibrin clot formation take
      Minutes
    • How long does fibrinolysis take
      Days
    • What are the roles of thrombin in blood coagulation
      To activate platelets and clotting factors.
    • What are the roles of platelets in blood coagulation
      To release platelet factors for the clotting cascade and form a platelet plug.
    • How are clotting factors activated
      They are converted from zymogens by proteolytic cleavage.
    • Why is a coagulation cascade used
      It allows for signal amplification
    • What type of feedback systems are used in the coagulation cascade
      Positive and negative.
    • What is symbol is used to donate that a factor is an enzyme
      a
    • What is used to donate that a factor is a co-factor
      A '
    • What is the name for Factor II
      Protothrombin
    • What is Factor II a
      Thrombin
    • What is factor I
      Fibrinogen
    • What is factor Ia
      Fibrin
    • What type of factor is III
      A tissue factor
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