Thermoregulation in humans: negative feedback loop
1. Cold: Stimulus: body is cold
2. The body's temperature is cooler than the hypothalamic set point
3. Heat-promoting centre in hypothalamus is activated
4. Vasoconstriction to minimise heat loss from skin surface, and skeletal muscles activated to shiver
5. Body temperature increases, and heat-promoting centre is shut off
6. Hot: Stimulus: body is hot
7. Heat loss centre in hypothalamus is activated
8. Vasodilation to allow heat loss from skin surface, sweat glands activated to secrete perspiration, vapourised by body heat
9. Body temperature decreases, heat loss centre is shut off