PKU is caused by the inheritance of two recessive genes, one from each parent. People with PKU are unable to break down the amino acid phenylalanine which builds up in the blood and brain causing mental retardation. However, if the child is diagnosed early, they are placed on a low protein diet for the first 12 years, which helps to avert this potentially lifelong disorder.Therefore, the disorder PKU (nature) is not expressed, because of an altered environment (low protein diet - nurture).