3.3.13.5 anti-cancer drugs

Cards (8)

cis-platin use 
anti-cancer drug
why is only the z-isomer of the drug effective?
cells in the natural world are chiral so it will be the correct orientation to 'fit the cells'
what does cisplatin have to be able to do?
bond to 2 adjacent guanine bases
how does cancer spread?
by replicating 'bad DNA'
what does cisplatin bond to?
strands of this mutated DNA to prevent it from replicating via ligand replacement with guanine
what causes the serious side effects of cisplatin?
it can occasionally bond to heated DNA strands
how are the side effects combatted?
the drug has to be administered in small amounts to try and reduce these effects
why is cisplatin used despite the side effects? 
its long-term benefits and effectiveness as an anticancer drug