James Simpson was a Scottish doctor who set out to find a way of easing the pain of childbirth.
He was not a particularly methodical worker. Instead, he would simply gather a bunch of his closest friends, and they would inhale a mixture of different chemicals to see if they would work.
In 1847, James Simpson experimented with chloroform by testing it on himself and two of his colleagues in his own dining room. When he awoke, he realised he might have a more effective anaesthetic than ever.
Although chloroform proved more pleasant for a patient than ever, it proved to be quite dangerous if it was not correctly administered. For example, in 1848, Hannah Greener fatally overdosed on chloroform whilst having a toenail removed.
The use of chloroform met with much resistance due to Hannah Greener's death.
An inhaler was created to control the dosage of chloroform.
The inhaler was used with Queen Victoria in 1853, during the birth of her eighth child, after that criticism dropped.
As the use of chloroform became more widespread, surgeons became more ambitious with their surgeries. They began occasionally operating when it wasn’t necessary, sometimes delving deeply into a person which increased the number of deaths by infection.