Some molecules are way too large to be taken into a cell by carrier proteins, e.g. proteins, lipids and some carbohydrates.
Instead a cell can surround a substance with a section of its plasma membrane.
The membrane then pinches off to form a vesicle inside the cell containing the ingested substance
the substance has been taken in by endocytosis
Some cells also take in much larger objects by endocytosis - for example, some white blood cells use endocytosis to take in things like microorganisms and dead cells so that they can destroy them.
Like active transport, this process uses ATP for energy.