methodological issue - there are several studies involving the role of dopamine and the frontal cortex involve the use of non-human animals, Although this allows researchers to study the effects of drugs in aways that are not possible with humans, the studies may not give a true insight into how humans become addicted. This is a criticism of research towards dopamine and addiction, suggesting that research conducted on non-human animals is difficult to generalise to human addiction, Additionally , we cannot replicate behavioural addictions such as gambling.