1. Injured blood vessel releases chemical messengers which attract platelets to the site
2. Collecting platelets rupture and release substances that combine with other blood components to produce an enzyme called thromboplastin
3. With the help of calcium ions, thromboplastin reacts with prothrombin (a protein secreted by the liver), producing thrombin
4. Thrombin reacts with fibrinogen (a protein found within the plasma) to produce fibrin
5. Fibrin strands act as a sort of mesh, preventing blood cells from escaping and forming a clot