Cytodifferentiation

• Cytodifferentiation starts when the neural tube is closed at the end of week four
• Neuroepithelial cells differentiatie into neuroblast cells, these wil prolifereate further to neurons and soms glia cells. the also produce the ependymal cells which line the central canal and brain vesicles
• Young neurons are formed in the ventricular or ependymal zone that surrounds the lumen of the neural tube. These neurons will migrate peripherally to establish the mantle or intermediate zone
• The intermediate zone contains the cell bodies of neurons that extend their axons peripherally to form the outermost marginal zone
• The mantle zone will differentiate into the gray matter
• The marginal zone develops into the white matter