hematopoiesis

• Haima = blood
• poiesis = making/formation/creation
• Renewal: Newly produced cells can return to

  the bone marrow and act as stem cells.
• Proliferation: Increase in the number of cells.
• Differentiation: Splitting into different cell

  types, such as myeloid and lymphoid

  lineages.
• Maturation: Growth and development of all

  blood cell lines.
• cytosis = high count
• penia = low count
• cytosis= thrombocytosis
• penia= leukopenia
• erythropoiesis- formation of erythrocyte
• leukopoiesis- formation of mature leukocytes
• throbopoiesis- production of platelets
• mesoblastic (primitive erythropoiesis)

  o as early as the 19th day gestation up to 3

  months

  o blood islands of the yolk sac of human embryo

  o only erythrocytes are made

  o intravascular (yolk sac)
• hb gower-1 = 2 zeta & 2 epsilon chain

  (primary
• hb gower-2 = 2 alpha & 2 epsilon
• hb portland = 2 zeta & 2 gamma
• hepatic (anything that relates to liver)

  o begins at 5 to 7 gestational weeks

  o lymphoid cells start to appear
• hepatic (anything that relates to liver)

  o megakaryopoiesis (eventually

  megakaryocyte will give rise to thrombocytes)

  begins

  o extravascular (liver)

  o 3rd month - fetal liver becomes active (peak)
• thymus - first fully developed organ

   major site of t-cell production

   maturation of t-cell = t for thy
• medullary (myeloid)

  o the hematopoiesis in the bone marrow

  o occurs in medulla or your inner part of the

  bone cavit
• medullary (myeloid)

  o begins between 4th and 5th month gestation

  o end of 6th month - bone marrow becomes the

  primary site
• medullary (myeloid)

  o mainly granulocytes (ben) are formed

  o ben = basophil, eosinophil, neutrophil
• medullary (myeloid)

  o all bone marrow are red - active

  hematopoiesis ~ fetal

  o yellow - inactive (fats) ~ in adults
• macrophages – phagocytic cells, capable of

  ingesting debris or other bacterias

  (neutrophils also is phagocytic)
• osteoclast – macrophage in the bone
• Lymphoid lineage – progenitor cell of B lymphocytes
• Lymphoid stem cell – precursor cell are B

  lymphoblast and T lymphoblast
• Precursor cell of B lymphocyte – B lymphoblast

  B lymphoblast will differentiate to B lymphocyte as well

  as T lymphoblast to T lymphocyt
• Natural killer cell – directly comes from lymphoid stem

  cell
• Proerythroblast – earliest precursor cell in the

  erythropoietic lineage
• Reticulocyte – precursor cell of erythrocyte
• Precursor term – cell before
• Basophilic erythroblast - precursor cells of

  polychromatic philic erythroblast
• Earliest precursor cell of erythrocyte -

  proerythroblast
• Red blood cell:

   Shape: biconcave, have central pallor,

  unucleated
• Red blood cell:

  Under microscope - rouleaux formation:

  stack of coins
• erythroblastic = europe
• normoblastic = americans
• rubriblast = parallels the granulopoiesis (b-e-

  n)