PROXIMAL TUBULE

• Proximal Tubule

  A) Simple Cuboidal

  B) Columnar Epithelial Cell

  C) Long Microvilli

  D) Cytoplasm

  E) More Eosinophilic

  F) Distal Convoluted Tubules

  G) Collecting Ducts

  
• ● 2 regions

  = Proximal convoluted tubule (PCT)

  = Pars recta

  • descending thick limb of Henle’s loop
• Proximal Tubules

  ● Simple cuboidal epithelium

  ● Microvilli

  + lateral processes

  + Resorption

  ● macromolecules and some ions from glomerular filtrate
• ★ MEDICAL APPLICATION

  = Diabetic glomerulosclerosis

  ■ Thickening and loss of function in the GBM produced as part of the systemic microvascular sclerosis in diabetes mellitus, is the leading cause of (irreversible) end-stage kidney disease in the United States.

  ■ Treatment requires either a kidney transplant or regular artificial hemodialysis.