Asexual Cycle

• Asexual Cycle (Schizogony)

  [Man: IH] (Infective stage to Man: Sporozoites)

  • Female Anopheles mosquito (DH) bites man, injecting sporozoites (IS) into the bloodstream.
• Asexual Cycle

  • Female Anopheles mosquito (DH) bites man, injecting sporozoites (IS) into the bloodstream.
• Asexual Cycle

  • Sporozoites infect liver cells and mature into schizonts which rupture and release merozoites. Some merozoites of P. vivax and P. ovale re-invade the liver cells forming hypnozoites, while the other species do not.
• Asexual Cycle

  • After initial replication in the liver (exo-erythrocytic schizogony), the parasites undergo asexual multiplication in the erythrocytes (erythrocytic schizogony).
• Asexual Cycle

  • Merozoites enter circulating RBCs (grow as ring form) where hemoglobin provides nutrition for their development into trophozoites.
• Asexual Cycle

  • The ring stage trophozoite mature into Schizont, contains merozoites, released on red cells rupture, each free to invade new cells.
• Asexual cycle

  • After a number of erythrocytic cycles, some merozoites develops onto gametocytes
• Asexual Cycle

  • (Microgametocyte: Male, Macrogametocyte: Female)