At rest, the arterio-venous difference is low as not much oxygen is required by the muscles. But during exercise, much more oxygen is needed from the blood for the muscles so the arterio-venous difference is high.
The increase in arterio-venous difference affects the body to change so more oxygen is taken in and more carbon dioxide is removed. Respiration also increases the arterio-venous difference as fitter performers can extract a greater amount of oxygen from the blood at rest and active.