Before investigations by Broca and Wernicke (and case of Phineas Gage), scientists generally supported holistic theory of the brain - all parts of brain involved in processing of thought and action. In contrast, Broca and Wernicke argued for localisation of function. Idea that diff parts of brain perform diff tasks and involved w/ diff parts of body. So if certain area of brain becomes damaged, the function associated w/ area will also be also be effected.