DENTURATION OF PROTEINS

• refers to the disruption and unfolding of protein

  Denaturation
• Denaturation's most common manifestation is when


  protein loses solubility in water
• results to either precipitation or coagulation

  Irreversible denaturation
• the sticking of molecules together to form a solid that will come out from the solution


  Precipitation
• the clumping of particles together in a solution.

  Coagulation
• cooking egg white converts it from a transparent liquid into a white solid that clumps together, known as?

  coagulum
• generally defined as metals with relatively high densities, atomic weights, or atomic numbers.

  Heavy metals
• essential nutrients


  iron, cobalt, and zinc
• relatively harmless


  ruthenium, silver, and indium
• Other heavy metals


  cadmium, mercury, and lead
• an acid derived from one or more inorganic compounds.

  mineral acid / inorganic acid
• All mineral acids dissociate in water to form?

  hydrogen ions and conjugate base
• are high molecular weight anions.

  Alkaloidal reagents
• The negative charge of these anions counteracts the positive charge of the amino groups of proteins giving a?


  precipitate
• Most alkaloidal reagents are astringent which causes


  constriction or shrinking of body tissues