The first major theory that had tried to explain what stuff is made out of was atomic theory
Atomic theory
The idea that everything is made up from tiny little particles that can't be broken down any further and that they're separated from each other by empty space
Democritus proposed atomic theory
Around 500 BC
When atomic theory was improved upon
1800s
John Dalton's atomic model
Atoms as solid spheres, different types of spheres make up different elements