PET scans; have showed that people with OCD have an increased amount of anxiety in the orbitofrontal cortex - OFC
worry circuit: the OFC identifies any worries, sending a worry signal to the caudate nucleus. From here, it filters the worry and determines whether it's a fear or not.
This needs serotonin to function properly, otherwise the efficiency may affected - without serotonin, the worry passes through and sends it into the thalamus.
As a result, the thalamus then becomes overwhelmed as it cannot determine whether the worry is a minor or major issue.