Oxygen transport

• BEARONS SAUGS TOGE and pugbal tea The deg p bw feats of if and the bed a sharp hips bete bestrede of his
• Wah the evolution of metesan orgasim -0.5 x 10" your apo e became dependent on as cxygen 10,1-baad recery afenergy from chemical bonds
• Vertebrates are a obic organies with a closed circulatory system and a mechanics for extraction of 0, from air (or water) and dease of carbon donde (CD,) te waste products
• Inspired D, les to an efickt atface of metabolic es such as glucose and fatty acids expired 00, is a major product of cellular meniles
• This union of O, as a metabolic substrate accompanied by the generation of free radical species that e capable of dorsaging virtually all biological macromol ales
• Orgations protect themselves from radical damag in several ways sequestering Oy, Amiting their production and aying then
• Tre poteric interestingly, parties pate these pro mechanians
• The major heme pro-teins in manuals are myoglobin (Mb) and hemoglobin (Hb)
• Myoglobin (Mb)


  Found primarily in sodetal and red miscan, serves to store O, in the cytoplasm and deliver it on deman to the minschonery
• Hemoglobin (Hb)


  Restricted to erytrogus mhare a fackicates the transport of, and C, betivern the Tune
• The introduction of 0, to the bats asserole In air of 21% in matures of gas, each cap Law) that is dredy geopertied to t
• It is also customary to use the part al peers ose ure efits concentration inplok had (101.3kascal or P 1 aranghae alte or the partial pressure ef y yo, is 150-160 mil
• The amount of O, in addation is, in tar, dreely proport as partial pressure
• In arterial blood (37°C 746 the po, is-100 mmHg, which predsa ce dbonded 0, of 0.11 mmol/l
• The lead of er, is inadequate to suppert oficiat reca 0, ho
• The major fraction of 0, tramparted blood and stored in muscle is complexed with the woo feren fey proteins Hb and Ms. respectively
• Hemoglobin (Hb)


  A tetric po with four O-binding sites there pup in anal o with a Hb concentration of 150g (2.3 saturation of 97.4%, the contration of pet bound is about 8.7 mmol/l
• The oxygen-carrying capacity of arterial blood, in desced and protein-bond kems is-8.3melt-alnost 100ml és solved oxygen per iter of blood
• Globine constitute an ancient bely el salable relaç boins whose structure and functions have been charactered mikroorganisms, plants enches and Present-day globins with their spectacular diversity of ke ton most likely evolved froes a single ancestral
• The extent of amino acid ideatty ang ina