5. Renal physiology 2 - Collins

• glomerular basement membrane (GBM) is responsible for most of the resistance to water flow across the glomerular barrier.
• Filtration coefficient (Kf ) depends on hydraulic conductance (permeability) and surface area
• Creatinine is a waste product produced by muscles
• At steady state, creatinine production = creatinine excretion.

  • there shouldn't be increase in creatinine level - if kidney is working
  • GFR can be estimated by plasma creatinine
• Colloid oncotic pressure (COP) increases in glomerular capillaries because of fluid exiting the blood leaving the plasma protein behind