Extreme weather like snow and strong winds are common.
Exposure to the cold can cause injury or death and also healthcare could be a long distance away.
Lack of sunlight, as it is so far north it experiences months without sunlight in the far north.
Cold temperatures and lack of sunlight make it extremely difficult place to build a home and then get suitable jobs in.
inaccessibility
Alaska is a long way from the rest of the USA.
This makes it difficult and expensive to access, often having to use air transport or dangerous ice roads.
Permafrost underlies most of Alaska so in summer you cannot go off-road due to this layer melting and causing your vehicle to get stuck in the permafrost.
Low population density of less than 1 person per sq. kilometre, means people are far away from employment opportunities and services like a doctor.
provision of buildings and infastructure
Construction work can only take place during the summer when there is daylight and warmer temperatures.
Old buildings sink into the ground when the permafrost melts which causes a lot of homes to be unsafe to live in.
New buildings today are raised on piles to prevent melting.
Airports runways are painted white to reflect sunlight and stop them from warming up too much on sunny days, so stopping damage to the runway through the permafrost melting.