Lec 4

• What genotype do individuals with the Bombay (O h) phenotype inherit?

  hh
• How do individuals with the Bombay (O h) phenotype type their blood?

  They type as an O in both forward and reverse testing.
• What is the consequence of having alloanti-H in individuals with the Bombay phenotype?

  It can activate complement and cause a hemolytic transfusion reaction.
• What type of blood can individuals with the Bombay phenotype be transfused with?

  They can only be transfused with Bombay group blood.
• How can blood for individuals with the Bombay phenotype be collected?

  Blood may be collected and frozen as autologous or from siblings who are also Bombay.
• What are the two alleles associated with secretor status?


  Se and se
• What does it mean for a person to inherit the Se allele?

  They are secretors and can express ABO and H antigens in their secretions.
• In which bodily fluids can A, B, and H antigens be found for secretors?

  Saliva, urine, tears, bile, amniotic fluid, breast milk, exudate, and digestive fluids.
• What is population genetics and its purpose?

  • Statistical calculation to determine the prevalence of antigens in specific populations.
  • Helps in understanding the frequency of antigens and compatibility in blood transfusions.
• How do you calculate the frequency of an antigen in a population?

  By determining the phenotype calculations.
• What should be done if a person has multiple antibodies in terms of compatibility?

  The frequency for each antibody must be multiplied to determine the percentage of compatible units.
• If the individual antigen probabilities in the population are 30% E-positive, what is the percentage of E-negative individuals?

  70%=0.7
• What is the percentage of M-negative individuals if 78% are M-positive?

  22%=0.2
• What is the percentage of c-negative individuals if 80% are c-positive?

  20%=0.2
• How do you predict the percentage of compatible units from individual probabilities?

  By multiplying the individual probabilities together.
• What is the predicted percentage of compatible units if the probabilities are 0.70, 0.22, and 0.20?

  0.03 or 3%